Our Pipeline
Retinal organoids from patient-derived cells, for human-relevant ophthalmic drug testing
Modeling the diseased retina
The retina is a layered tissue in which several cell types interact. We co-culture Müller glia, retinal pigment epithelium (RPE) and vascular endothelial cells and design retina-specific ECM hydrogels to reproduce the microenvironment of diabetic retinopathy.
Patient-derived ocular cells from our clinical partner let us build datasets that separate disease, normal control and drug-treated groups.
Target indications
DR
Diabetic retinopathy
Retinal vascular disease caused by diabetes; over 100 million patients worldwide.
AMD
Age-related macular degeneration
A leading cause of vision loss in older adults.
RP
Retinitis pigmentosa
Inherited degeneration of the retina.
ERM
Epiretinal membrane
A fibrous membrane forming on the macular surface.
Development plan
| Stage | Work | Success criteria |
|---|---|---|
| Year 1 | Port Pocket plate design, culture optimization for a four-cell panel, fluorescence training data and QC procedures | ≥3,000 valid images; ≥85% image QC pass rate |
| Year 2 | Patient-derived ocular cell panel, early toxicity and viability models, external PoC | ≥70% initial culture success; early toxicity ROC ≥0.85 |
| 2026–2028 | Ophthalmic disease organoids and drug response prediction | Analysis service for pharma |